How long the effects last depend on the size of the clot, how easily the medicines dissolve the clot, and why the clot formed.

Many of the symptoms will get better with treatment, but you may have less energy and stamina for several weeks. Most people need to take blood thinners for 3 to 6 months. People who have a very high risk of getting more clots may need to take blood thinners for life.

Follow the treatment prescribed by your doctor. Make sure you understand how to take your medicines and follow the instructions exactly. Make sure you have all the blood tests recommended by your doctor to check how well your blood thinner is working.  Avoid pain medicines such as aspirin, ibuprofen (Motrin, Advil, Nuprin), and naproxen (Naprosyn, Aleve). These medicines may cause bleeding or ulcers. Be sure that you tell all doctors who treat you about all the products (prescription, nonprescription, supplements, natural remedies, and vitamins) you are taking.  Blood thinners will make you bleed more than usual. To help prevent cuts, consider wearing rubber gloves or garden gloves for household and outdoor work. Don't walk barefoot.  Do not smoke.  Watch for signs of swelling in your legs.  Put your legs up and wear special elastic stockings if prescribed by your doctor.  Ask your doctor how soon you can start or go back to a regular exercise program.

To help prevent blood clots from forming, get regular exercise according to your doctor's recommendation.  If you are bedridden or recovering from major surgery, your doctor may prescribe a blood thinner to prevent clots from forming while you are inactive.  If you travel long distances, be sure to stand and walk often (for example, get up every hour, and move your legs and feet while you are sitting). Don't sit cross-legged on long trips.  Unless your doctor has asked you to limit liquids, drink plenty of fluids.  If you are planning surgery, ask your doctor what can be done to prevent blood clots.  Do not smoke.  Avoid wearing anything on the legs that restricts the return of blood from the feet to the heart such as knee high hose that have an elastic band at the top of them.